A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: The empirical basis for U.S. clinical practice.

Andrew D. Krystal, MD

Director of Sleep Research Laboratory and Insomnia Program
Professor of Psychiatry and Behavioral Sciences
Duke University School of Medicine
Durham, North Carolina

Insomnia is one of the most common sleep complaints of patients presenting to primary care physicians. Treatment has been facilitated by evidence obtained from rigorously controlled studies evaluating the risks and benefits of pharmacological treatment options over long durations and in patients with conditions commonly comorbid with insomnia. Studies in elderly and pediatric patient populations are still lacking, which may lead to suboptimal treatment in these groups.

References

Krystal AD. A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: The empirical basis for U.S. clnical practice. Sleep Med Rev. 2009 Aug;13(4):265-274. Epub 2009. Jan 18.

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